MONDAY, Aug. 16, 2021 (HealthDay Information) — COVID-19 vaccination triggers a robust immune response in individuals with HIV, which means they’re possible protected in opposition to the coronavirus, a brand new, small research reveals.
“Earlier analysis has instructed a suboptimal response to COVID-19 vaccines in individuals living with HIV; nevertheless, these research didn’t absolutely characterize and outline that response, each for mobile [the place the immune system instantly assaults contaminated cells] and humoral [where the immune system circulates virus-fighting antibodies] immunity,” stated senior research writer Dr. Joel Blankson. He’s a professor of medication on the Johns Hopkins College College of Medication, in Baltimore.
“What we discovered with the extensively used Pfizer/BioNTech vaccine was simply the other, because it induces strong immune responses in individuals residing with HIV, akin to these seen in wholesome individuals,” he defined in a Hopkins information launch.
For the research, Blankson and his colleagues analyzed blood samples collected from seven ladies and 5 males with HIV and from seven ladies and 10 males with out HIV between seven and 17 days after they acquired their second dose of the two-dose Pfizer vaccine.
Not one of the individuals had proof of prior an infection with the coronavirus (SARS-CoV-2) that causes COVID-19.
All the individuals with HIV have been on antiretroviral remedy and had a median CD4+ T-cell rely of 913 cells per microliter. Ranges of those immune cells in a wholesome grownup are between 500 to 1,200 cells per microliter, whereas individuals with untreated HIV could have counts decrease than 200 cells per microliter.
CD4+ T-cells are additionally referred to as helper T-cells as a result of they help one other sort of immune cell referred to as B-cells in responding to floor proteins (antigens) on viruses corresponding to SARS-CoV-2, the researchers defined.
The researchers additionally checked for the presence and ranges of antibodies in opposition to the protein making up the spikes that protrude from the floor of the coronavirus within the individuals after they’d been absolutely vaccinated.
“We discovered that there was no important distinction in both the vaccine-produced CD4+ T-cell responses or the titers [levels] of SARS-CoV-2 spike binding antibodies for wholesome individuals and people residing with HIV,” Blankson stated. “This means that individuals residing with HIV might be adequately protected in opposition to SARS-CoV-2, with correct vaccination.”
The research was revealed on-line not too long ago within the journal Clinical Infectious Diseases.
Additional analysis is required to find out if individuals with HIV who’ve decrease CD4+ T-cell counts get the identical robust mobile and humoral immune responses to COVID-19 vaccines because the individuals on this research, Blankson stated.
HIV.gov has extra on COVID-19 and people with HIV.
SOURCE: Johns Hopkins Medication, information launch, Aug. 11, 2021